{"id":3152,"date":"2025-11-25T14:45:26","date_gmt":"2025-11-25T14:45:26","guid":{"rendered":"https:\/\/theinformantusa.com\/?p=3152"},"modified":"2025-11-25T14:45:29","modified_gmt":"2025-11-25T14:45:29","slug":"%f0%9f%9a%a8-new-jama-study-links-stopping-glp-1-drugs-before-or-early-in-pregnancy-to-increased-risks","status":"publish","type":"post","link":"https:\/\/theinformantusa.com\/?p=3152","title":{"rendered":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks"},"content":{"rendered":"\n

Women Who Discontinue Ozempic or Mounjaro Face Higher Risk of Excessive Weight Gain, <\/strong>
Gestational Diabetes, and Preterm Birth<\/strong><\/h2>\n\n\n\n

A large new study published in JAMA Internal Medicine confirms that women who stop GLP-1 receptor agonists such as semaglutide (Ozempic) and tirzepatide (Mounjaro) shortly before or at the start of pregnancy face a higher risk of excessive gestational weight gain, gestational diabetes, and preterm birth.<\/strong><\/p>\n\n\n\n

The retrospective cohort analysis examined nearly 150,000 pregnancies across the United States between 2016 and 2025, comparing pregnancy outcomes between women exposed to GLP-1 receptor agonists around conception and those who were not.<\/p>\n\n\n\n

Researchers found that cessation of these drugs leads to a rapid metabolic rebound effect, resulting in increased pregnancy complications, although the study does not establish definitive causality.<\/p>\n\n\n\n

Among the exposed group, rates of excess gestational weight gain, gestational diabetes, and premature delivery were significantly higher compared to matched controls.<\/p>\n\n\n\n

The study did not find differences in birth length, rates of infants large or small for gestational age, or cesarean section frequency.<\/p>\n\n\n\n

The authors emphasize the importance of close clinical monitoring and improved nutritional and weight management strategies for women discontinuing GLP-1 therapy due to pregnancy.<\/p>\n\n\n\n

While GLP-1 drugs are effective for weight loss and diabetes management, they are generally not recommended during pregnancy, with official guidelines advising cessation two months prior to conception.<\/p>\n\n\n\n

The findings illustrate the urgent need for personalized care to mitigate risks in this vulnerable population.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Women Who Discontinue Ozempic or Mounjaro Face Higher Risk of Excessive Weight Gain, Gestational Diabetes, and Preterm Birth A large new study published in JAMA Internal Medicine confirms that women who stop GLP-1 receptor agonists such as semaglutide (Ozempic) and tirzepatide (Mounjaro) shortly before or at the start of pregnancy face a higher risk of […]<\/p>\n","protected":false},"author":2,"featured_media":3153,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[771,9,1169,939,935,1170],"class_list":["post-3152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle","tag-771","tag-health","tag-jamastudy","tag-mounjaro","tag-ozempic","tag-pregnancy"],"yoast_head":"\n\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/theinformantusa.com\/?p=3152\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA\" \/>\n<meta property=\"og:description\" content=\"Women Who Discontinue Ozempic or Mounjaro Face Higher Risk of Excessive Weight Gain, Gestational Diabetes, and Preterm Birth A large new study published in JAMA Internal Medicine confirms that women who stop GLP-1 receptor agonists such as semaglutide (Ozempic) and tirzepatide (Mounjaro) shortly before or at the start of pregnancy face a higher risk of […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/theinformantusa.com\/?p=3152\" \/>\n<meta property=\"og:site_name\" content=\"The Informant USA\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=61575215453941\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-25T14:45:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-25T14:45:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y-1024x683.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"THE INFORMANT USA EDITORIAL\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@TheInformantUSA\" \/>\n<meta name=\"twitter:site\" content=\"@TheInformantUSA\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"THE INFORMANT USA EDITORIAL\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#article\",\"isPartOf\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152\"},\"author\":{\"name\":\"THE INFORMANT USA EDITORIAL\",\"@id\":\"https:\/\/theinformantusa.com\/#\/schema\/person\/a225d759aad5f3e3286992983049831b\"},\"headline\":\"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks\",\"datePublished\":\"2025-11-25T14:45:26+00:00\",\"dateModified\":\"2025-11-25T14:45:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152\"},\"wordCount\":248,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/theinformantusa.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#primaryimage\"},\"thumbnailUrl\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png\",\"keywords\":[\"2025\",\"Health\",\"JAMAStudy\",\"Mounjaro\",\"Ozempic\",\"Pregnancy\"],\"articleSection\":[\"LIFESTYLE\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/theinformantusa.com\/?p=3152#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/theinformantusa.com\/?p=3152\",\"url\":\"https:\/\/theinformantusa.com\/?p=3152\",\"name\":\"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA\",\"isPartOf\":{\"@id\":\"https:\/\/theinformantusa.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#primaryimage\"},\"image\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#primaryimage\"},\"thumbnailUrl\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png\",\"datePublished\":\"2025-11-25T14:45:26+00:00\",\"dateModified\":\"2025-11-25T14:45:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/theinformantusa.com\/?p=3152\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#primaryimage\",\"url\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png\",\"contentUrl\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png\",\"width\":1536,\"height\":1024,\"caption\":\"Stopping Ozempic or Mounjaro Before Pregnancy Raises Risks, JAMA Study Finds\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/theinformantusa.com\/?p=3152#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/theinformantusa.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/theinformantusa.com\/#website\",\"url\":\"https:\/\/theinformantusa.com\/\",\"name\":\"The Informant USA\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/theinformantusa.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/theinformantusa.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/theinformantusa.com\/#organization\",\"name\":\"The Informant USA\",\"url\":\"https:\/\/theinformantusa.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/theinformantusa.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/05\/THE-INFORMANT-USA-OFI-B.png\",\"contentUrl\":\"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/05\/THE-INFORMANT-USA-OFI-B.png\",\"width\":1080,\"height\":1080,\"caption\":\"The Informant USA\"},\"image\":{\"@id\":\"https:\/\/theinformantusa.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/profile.php?id=61575215453941\",\"https:\/\/x.com\/TheInformantUSA\",\"https:\/\/www.instagram.com\/theinformantusa\/\",\"https:\/\/www.tiktok.com\/@theinformantusa\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/theinformantusa.com\/#\/schema\/person\/a225d759aad5f3e3286992983049831b\",\"name\":\"THE INFORMANT USA EDITORIAL\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/theinformantusa.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/56273392fc0176bb507cd935f1cfc790a1db84203e9b0e0691468fcdd7dc8530?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/56273392fc0176bb507cd935f1cfc790a1db84203e9b0e0691468fcdd7dc8530?s=96&d=mm&r=g\",\"caption\":\"THE INFORMANT USA EDITORIAL\"},\"url\":\"https:\/\/theinformantusa.com\/?author=2\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/theinformantusa.com\/?p=3152","og_locale":"en_US","og_type":"article","og_title":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA","og_description":"Women Who Discontinue Ozempic or Mounjaro Face Higher Risk of Excessive Weight Gain, Gestational Diabetes, and Preterm Birth A large new study published in JAMA Internal Medicine confirms that women who stop GLP-1 receptor agonists such as semaglutide (Ozempic) and tirzepatide (Mounjaro) shortly before or at the start of pregnancy face a higher risk of […]","og_url":"https:\/\/theinformantusa.com\/?p=3152","og_site_name":"The Informant USA","article_publisher":"https:\/\/www.facebook.com\/profile.php?id=61575215453941","article_published_time":"2025-11-25T14:45:26+00:00","article_modified_time":"2025-11-25T14:45:29+00:00","og_image":[{"width":1024,"height":683,"url":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y-1024x683.png","type":"image\/png"}],"author":"THE INFORMANT USA EDITORIAL","twitter_card":"summary_large_image","twitter_creator":"@TheInformantUSA","twitter_site":"@TheInformantUSA","twitter_misc":{"Written by":"THE INFORMANT USA EDITORIAL","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/theinformantusa.com\/?p=3152#article","isPartOf":{"@id":"https:\/\/theinformantusa.com\/?p=3152"},"author":{"name":"THE INFORMANT USA EDITORIAL","@id":"https:\/\/theinformantusa.com\/#\/schema\/person\/a225d759aad5f3e3286992983049831b"},"headline":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks","datePublished":"2025-11-25T14:45:26+00:00","dateModified":"2025-11-25T14:45:29+00:00","mainEntityOfPage":{"@id":"https:\/\/theinformantusa.com\/?p=3152"},"wordCount":248,"commentCount":0,"publisher":{"@id":"https:\/\/theinformantusa.com\/#organization"},"image":{"@id":"https:\/\/theinformantusa.com\/?p=3152#primaryimage"},"thumbnailUrl":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png","keywords":["2025","Health","JAMAStudy","Mounjaro","Ozempic","Pregnancy"],"articleSection":["LIFESTYLE"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/theinformantusa.com\/?p=3152#respond"]}]},{"@type":"WebPage","@id":"https:\/\/theinformantusa.com\/?p=3152","url":"https:\/\/theinformantusa.com\/?p=3152","name":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks - The Informant USA","isPartOf":{"@id":"https:\/\/theinformantusa.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/theinformantusa.com\/?p=3152#primaryimage"},"image":{"@id":"https:\/\/theinformantusa.com\/?p=3152#primaryimage"},"thumbnailUrl":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png","datePublished":"2025-11-25T14:45:26+00:00","dateModified":"2025-11-25T14:45:29+00:00","breadcrumb":{"@id":"https:\/\/theinformantusa.com\/?p=3152#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/theinformantusa.com\/?p=3152"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/theinformantusa.com\/?p=3152#primaryimage","url":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png","contentUrl":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/11\/20251125_0840_Medical-Consultation-Scene_simple_compose_01kaxq75vfe1088wf6aakymg9y.png","width":1536,"height":1024,"caption":"Stopping Ozempic or Mounjaro Before Pregnancy Raises Risks, JAMA Study Finds"},{"@type":"BreadcrumbList","@id":"https:\/\/theinformantusa.com\/?p=3152#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/theinformantusa.com\/"},{"@type":"ListItem","position":2,"name":"\u00a0\ud83d\udea8 New JAMA Study Links Stopping GLP-1 Drugs Before or Early in Pregnancy to Increased Risks"}]},{"@type":"WebSite","@id":"https:\/\/theinformantusa.com\/#website","url":"https:\/\/theinformantusa.com\/","name":"The Informant USA","description":"","publisher":{"@id":"https:\/\/theinformantusa.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/theinformantusa.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/theinformantusa.com\/#organization","name":"The Informant USA","url":"https:\/\/theinformantusa.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/theinformantusa.com\/#\/schema\/logo\/image\/","url":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/05\/THE-INFORMANT-USA-OFI-B.png","contentUrl":"https:\/\/theinformantusa.com\/wp-content\/uploads\/2025\/05\/THE-INFORMANT-USA-OFI-B.png","width":1080,"height":1080,"caption":"The Informant USA"},"image":{"@id":"https:\/\/theinformantusa.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/profile.php?id=61575215453941","https:\/\/x.com\/TheInformantUSA","https:\/\/www.instagram.com\/theinformantusa\/","https:\/\/www.tiktok.com\/@theinformantusa"]},{"@type":"Person","@id":"https:\/\/theinformantusa.com\/#\/schema\/person\/a225d759aad5f3e3286992983049831b","name":"THE INFORMANT USA EDITORIAL","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/theinformantusa.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/56273392fc0176bb507cd935f1cfc790a1db84203e9b0e0691468fcdd7dc8530?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/56273392fc0176bb507cd935f1cfc790a1db84203e9b0e0691468fcdd7dc8530?s=96&d=mm&r=g","caption":"THE INFORMANT USA EDITORIAL"},"url":"https:\/\/theinformantusa.com\/?author=2"}]}},"_links":{"self":[{"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/posts\/3152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3152"}],"version-history":[{"count":1,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/posts\/3152\/revisions"}],"predecessor-version":[{"id":3154,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/posts\/3152\/revisions\/3154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=\/wp\/v2\/media\/3153"}],"wp:attachment":[{"href":"https:\/\/theinformantusa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/theinformantusa.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}